HEMATOPOIESIS AND STEM CELLS The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

نویسندگان

  • Steven W. Lane
  • Stephen M. Sykes
  • Fatima Al-Shahrour
  • Sebastian Shterental
  • Mahnaz Paktinat
  • Cristina Lo Celso
  • Jonathan L. Jesneck
  • Benjamin L. Ebert
  • David A. Williams
  • Gary Gilliland
چکیده

1Department of Hematology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; 2Department of Hematology/Oncology, Children’s Hospital Boston, Harvard Medical School, MA; 3University of Queensland Medical School, Brisbane, Australia; 4Department of Stem Cell and Regenerative Biology, Harvard Medical School, Massachusetts General Hospital, Boston; 5Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; 6Cancer Program, Broad Institute, Cambridge MA; and 7Merck Research Laboratories, North Wales, PA

منابع مشابه

Effect of daunorubicin drug with and without cimetidine on the nucleated cells of bone marrow of balb/c mouse

Introduction: Hematopoiesis is an on going process mammalian marrow system. A few cells from the nucleated cells of bone marrow are hematopoietic cells which include primary stem cells, precursor cells and progenitor cells. Primary stem cells and progenitor cells are able to produce colonies in culture medium (CFU-C) and irradiated mouse spleen (CFU-S). A hematopoietic cell is alive and act...

متن کامل

Pre-treatment with rapamycin protects hematopoiesis against radiation injury

Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...

متن کامل

JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells

The AP-1 transcription factor JunB is a transcriptional regulator of myelopoiesis. Inactivation of JunB in postnatal mice results in a myeloproliferative disorder (MPD) resembling early human chronic myelogenous leukemia (CML). Here, we show that JunB regulates the numbers of hematopoietic stem cells (HSC). JunB overexpression decreases the frequency of long-term HSC (LT-HSC), while JunB inacti...

متن کامل

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

Although the concept of a leukemic stem cell system has recently been well accepted, its nature and the underlying molecular mechanisms remain obscure. Constitutive activation of signal transducers and activators of transcription 3 (STAT3) and STAT5 is frequently detected in various hematopoietic tumors. To evaluate their role in normal and leukemic stem cells, we took advantage of constitutive...

متن کامل

بررسی اثر آگونیست -آدرنرژیکی ایزوپروترنول بر بیان miR-886-3p و miR-23a در سلولهای بنیادی مزانشیمی مغز استخوان انسان

Background and Objective: Mobilization of Hematopoietic Stem Cells (HSCs) for transplantation and the importance of -adrenergic signals in induction of this process have been well investigated. However, little is known about the role of -adrenergic signals in mobilization of HSCs and factors influenced by these signals. The Chemokine Stromal Derived Factor -1 (SDF-1) which is expressed by hum...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

متن کامل
عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010